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XEOMIN® (Zeo-min) (incobotulinumtoxinA) for injection, for intramuscular use is indicated for the temporary improvement in the appearance of moderate to severe glabellar (between the eyebrows), lines with corrugator and/or procerus muscle activity in adult patients.

How does XEOMIN work?


When you squint or frown, the muscles between your eyebrows contract, causing the skin to furrow and fold. Over time, as your skin ages and loses some of its elasticity, these repeated contractions can cause persistent frown lines. Botulinum toxin type A – the active ingredient in XEOMIN®– acts on nerve endings in muscles to prevent muscle fibers from contracting. By reducing these contractions, XEOMIN® can temporarily reduce the lines between your eyebrows, so frown lines are softened.


XEOMIN® is made through a unique precision manufacturing process that isolates the therapeutic component of the molecule and removes the accessory proteins that don’t play an active role in treatment. XEOMIN® is a highly purified neurotoxin. Studies have not been performed to determine whether the presence or absence of accessory proteins has a long-term effect on safety or efficacy.

What can I expect during treatment?

During treatment, which usually takes about 10-20 minutes, your doctor will inject XEOMIN® into the muscles in your forehead that cause frown lines between your eyebrows. No anesthesia is required.

When can I expect to see results?

You may begin to see visible smoothing as early as 3-4 days after injection. The median first onset of effect was less than a week. The maximum effect occurred at 30 days. The typical duration of effect was up to 3 months in clinical trials but may last significantly longer or shorter in individual patients.

Are you concerned about looking plastic or overdone?

Looking plastic or overdone is a common concern among individuals considering an in-office treatment for moderate to severe frown lines. There are steps we can take to make you feel more comfortable. First, having a detailed discussion with you regarding your concerns or questions until you feel comfortable is my first priority. Second, we will determine together after our discussion which treatment options are the right ones for you. For example, the most widely used procedure for moderate to severe frown lines are neurotoxin injections, such as XEOMIN®. Finally, while individual results may vary, using FDA-approved products, such as XEOMIN® should leave you knowing we are here to provide the best care possible.

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